Underground Biohacking

KPV dosing calculator

CompoundKPV
mg
mL

1 mg = 1000 mcg.

Your syringe
Draw this much

Enter a vial size, water volume and dose to see where to pull.

51015202530102030
0 units0.3 mL barrel, U-100 scale30 units

For tracking and calculation purposes only. Not medical advice. Based on a standard U-100 insulin syringe.

This calculator has no pre-filled dose for KPV. We pre-fill a dose only from an approved label or a human trial arm that fits this tool, and none does.

How the units are worked out

Your vial holds a fixed amount of peptide. The water you add sets the concentration (how much peptide sits in each millilitre). The concentration then decides how much liquid carries your dose.

Three steps, in order:

  1. Concentration (mcg/mL) = peptide in the vial (mcg) divided by water added (mL).
  2. Volume (mL) = your dose (mcg) divided by the concentration (mcg/mL).
  3. Units to draw = volume (mL) multiplied by 100.

That last step is the syringe, not the peptide. A U-100 insulin syringe is marked so 100 units hold 1 mL, so 0.1 mL reads as 10 units.

A worked example

Enter your dose in the calculator above and this line shows the numbers worked through.

Water and units at a glance

KPV at different mixes. Every row opens the calculator on that mix.

VialWaterConcentration
10 mg1 mL10,000 mcg/mL
10 mg2 mL5,000 mcg/mL
10 mg3 mL3,333 mcg/mL
10 mg5 mL2,000 mcg/mL

Units appear once you enter a dose.

The pre-filled vial size is the most-used size in WPA dosing data (Aug 2026), or our vendors' most common size where WPA data is thin. The water is the most-used amount in WPA data. There is no pre-filled dose. Not a recommendation.

Mixing and storage

Run the water down the inside wall of the vial and let the powder dissolve on its own. Never shake it. Label the vial with the compound, the total mass, the water you added, the concentration and the date. A sealed freeze-dried vial keeps 12 to 24 months in the fridge at 2 to 8°C. Once mixed with preserved water, such as bacteriostatic water, that drops to roughly 28 days refrigerated. Keep it at the back of the fridge, away from light and away from the door's temperature swings.

Other compounds

Questions

Can you take KPV and BPC-157 together?
No study has tested that combination. Both peptides are researched on their own, and neither has published human trial data. Stacking them is an untested experiment, not a protocol with evidence behind it.
How often should I take KPV peptide?
No dosing schedule has been tested in people. The mouse studies dosed continuously, usually by adding KPV to drinking water, across the whole experiment. That does not convert into a human schedule, and nobody has published one.
How long does it take KPV peptide to work?
Nobody knows, because it has never been measured in people. The animal studies checked whether the gut had recovered by the end of the experiment, not how fast the effect started. There is no human time course to read across.
Does KPV peptide help with weight loss?
No. No study has looked at KPV and fat loss. The weight gain reported in the colitis studies was sick animals recovering from illness, not healthy animals getting leaner.
Why is the gut the main area of KPV research?
Because that is where KPV gets in. It rides into intestinal cells on PepT1, a transporter the gut increases during inflammatory bowel disease. That gives a swallowed dose a direct route into inflamed tissue, which most peptides do not have.
Is KPV FDA approved?
No. The FDA has not approved KPV for any use. Its own compounding pages say two things. The FDA has found no human exposure data for KPV by any route. And it lacks the information it would need to know whether KPV would cause harm in people.

References

  1. 01Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. PMID: 18061177. DOI: 10.1053/j.gastro.2007.10.026.
  2. 02Kannengiesser K, Maaser C, Heidemann J, et al. (2008). Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflammatory Bowel Diseases. PMID: 18092346. DOI: 10.1002/ibd.20334.
  3. 03Getting SJ, Schioth HB, Perretti M. (2003). Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. Journal of Pharmacology and Experimental Therapeutics. PMID: 12750433. DOI: 10.1124/jpet.103.051623.
  4. 04Xiao B, Xu Z, Viennois E, et al. (2017). Orally targeted delivery of tripeptide KPV via hyaluronic acid-functionalized nanoparticles efficiently alleviates ulcerative colitis. Molecular Therapy. PMID: 28143741. DOI: 10.1016/j.ymthe.2016.11.020.
  5. 05Land SC. (2012). Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. International Journal of Physiology, Pathophysiology and Pharmacology. PMID: 22837805.
  6. 06Sun J, Xue P, Liu J, et al. (2021). Self-cross-linked hydrogel of cysteamine-grafted gamma-polyglutamic acid stabilized tripeptide KPV for alleviating TNBS-induced ulcerative colitis in rats. ACS Biomaterials Science and Engineering. PMID: 34547895. DOI: 10.1021/acsbiomaterials.1c00792.
  7. 07Zhao Y, Xue P, Lin G, et al. (2022). A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon. Acta Biomaterialia. PMID: 35245681. DOI: 10.1016/j.actbio.2022.02.039.
  8. 08Pawar K, Kolli CS, Rangari VK, Babu RJ. (2017). Transdermal iontophoretic delivery of lysine-proline-valine (KPV) peptide across microporated human skin. Journal of Pharmaceutical Sciences. PMID: 28343991. DOI: 10.1016/j.xphs.2017.03.017.
  9. 09Songok AC, Panta P, Doerrler WT, et al. (2018). Structural modification of the tripeptide KPV by reductive glycoalkylation of the lysine residue. PLoS One. PMID: 29953505. DOI: 10.1371/journal.pone.0199686.
  10. 10Pawar KR, Mulabagal V, Smith F, et al. (2014). Stability-indicating HPLC assay for lysine-proline-valine (KPV) in aqueous solutions and skin homogenates. Biomedical Chromatography. PMID: 25298219. DOI: 10.1002/bmc.3347.
Chris Hallewell, founder of Underground Biohacking

By , Founder, Underground Biohacking

Last reviewed

The numbers here describe your own vial. They are not medical advice and not a dose suggestion. Confirm your protocol with a qualified clinician.

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