KPV dosing calculator
1 mg = 1000 mcg.
0.100 mL · 5,000 mcg/mL
- Doses per vial
- 20
- Per unit
- 50 mcg
- One vial lasts
- 20 days at 1/day
Your draw
www.undergroundbiohacking.com · For tracking and calculation purposes only. Not medical advice.
For tracking and calculation purposes only. Not medical advice. Based on a standard U-100 insulin syringe.
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How the units are worked out
Your vial holds a fixed amount of peptide. The water you add sets the concentration (how much peptide sits in each millilitre). The concentration then decides how much liquid carries your dose.
Three steps, in order:
- Concentration (mcg/mL) = peptide in the vial (mcg) divided by water added (mL).
- Volume (mL) = your dose (mcg) divided by the concentration (mcg/mL).
- Units to draw = volume (mL) multiplied by 100.
That last step is the syringe, not the peptide. A U-100 insulin syringe is marked so 100 units hold 1 mL, so 0.1 mL reads as 10 units.
A worked example
These are the numbers in the calculator above, worked through: 10 mg + 2 mL = 5,000 mcg/mL. 500 mcg = 0.10 mL = 10 units on a 0.3 mL syringe.
Change any number in the tool and this line changes with it. The link in your address bar carries the numbers, so you can save it or send it to yourself.
Water and units at a glance
The same dose of KPV at different mixes. Every row opens the calculator on that mix.
| Vial | Water | Concentration | Units to draw |
|---|---|---|---|
| 10 mg | 1 mL | 10,000 mcg/mL | 5 units |
| 10 mg | 2 mL | 5,000 mcg/mL | 10 units |
| 10 mg | 3 mL | 3,333 mcg/mL | 15 units |
| 10 mg | 5 mL | 2,000 mcg/mL | 25 units |
Pre-filled numbers are the most-used setups reported by users of public calculators (WPA dosing data, Aug 2026). Not a recommendation.
Mixing and storage
Run the water down the inside wall of the vial and let the powder dissolve on its own. Never shake it. Label the vial with the compound, the total mass, the water you added, the concentration and the date. A sealed freeze-dried vial keeps 12 to 24 months in the fridge at 2 to 8°C. Once mixed with preserved water, such as bacteriostatic water, that drops to roughly 28 days refrigerated. Keep it at the back of the fridge, away from light and away from the door's temperature swings.
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Questions
Can you take KPV and BPC-157 together?
How often should I take KPV peptide?
How long does it take KPV peptide to work?
Does KPV peptide help with weight loss?
Why is the gut the main area of KPV research?
Is KPV FDA approved?
References
- 01Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. PMID: 18061177. DOI: 10.1053/j.gastro.2007.10.026.
- 02Kannengiesser K, Maaser C, Heidemann J, et al. (2008). Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflammatory Bowel Diseases. PMID: 18092346. DOI: 10.1002/ibd.20334.
- 03Getting SJ, Schioth HB, Perretti M. (2003). Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. Journal of Pharmacology and Experimental Therapeutics. PMID: 12750433. DOI: 10.1124/jpet.103.051623.
- 04Xiao B, Xu Z, Viennois E, et al. (2017). Orally targeted delivery of tripeptide KPV via hyaluronic acid-functionalized nanoparticles efficiently alleviates ulcerative colitis. Molecular Therapy. PMID: 28143741. DOI: 10.1016/j.ymthe.2016.11.020.
- 05Land SC. (2012). Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. International Journal of Physiology, Pathophysiology and Pharmacology. PMID: 22837805.
- 06Sun J, Xue P, Liu J, et al. (2021). Self-cross-linked hydrogel of cysteamine-grafted gamma-polyglutamic acid stabilized tripeptide KPV for alleviating TNBS-induced ulcerative colitis in rats. ACS Biomaterials Science and Engineering. PMID: 34547895. DOI: 10.1021/acsbiomaterials.1c00792.
- 07Zhao Y, Xue P, Lin G, et al. (2022). A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon. Acta Biomaterialia. PMID: 35245681. DOI: 10.1016/j.actbio.2022.02.039.
- 08Pawar K, Kolli CS, Rangari VK, Babu RJ. (2017). Transdermal iontophoretic delivery of lysine-proline-valine (KPV) peptide across microporated human skin. Journal of Pharmaceutical Sciences. PMID: 28343991. DOI: 10.1016/j.xphs.2017.03.017.
- 09Songok AC, Panta P, Doerrler WT, et al. (2018). Structural modification of the tripeptide KPV by reductive glycoalkylation of the lysine residue. PLoS One. PMID: 29953505. DOI: 10.1371/journal.pone.0199686.
- 10Pawar KR, Mulabagal V, Smith F, et al. (2014). Stability-indicating HPLC assay for lysine-proline-valine (KPV) in aqueous solutions and skin homogenates. Biomedical Chromatography. PMID: 25298219. DOI: 10.1002/bmc.3347.
By Chris Hallewell, Founder, Underground Biohacking
Last reviewed
The numbers here describe your own vial. They are not medical advice and not a dose suggestion. Confirm your protocol with a qualified clinician.
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