MOTS-c
Mechanism
A 16-amino-acid mitochondrial-derived peptide. Activates AMPK signalling, improves insulin sensitivity, and enhances metabolic flexibility. Endogenous expression rises with exercise; declines with age.
Typical dose
5-10mg per injection, 2-3 times per week
Cycle length
8-12 weeks on, 4-8 weeks off
Form
Injectable (subcutaneous or intramuscular)
MOTS-c protocols
Deep dives on MOTS-c
- Which Peptides Are Legal Again in 2026? The Full FDA ListComplete guide to the 14 peptides returning to legal compounding status in 2026 after RFK Jr.'s FDA reclassification announcement. Every compound explained.
- What the FDA Reclassification Actually Means for Peptide UsersLearn how to evaluate peptide suppliers, read a third-party COA, spot counterfeits, and verify lab testing quality after the 2026 FDA reclassification.
- 6 Best Peptides for Anti-Ageing and Longevity (2026)The anti-ageing peptide consensus is wrong. We rank epitalon, MOTS-c, and GHK-Cu by what the primary literature actually proves vs what marketing narratives claim.
- 5 Best Peptides for Gut Health and InflammationThe 5 best peptides for gut health and inflammation ranked by evidence: BPC-157, TB-500, GHK-Cu, KPV, and MOTS-c. Mechanisms, dosing, and clinical data explained.
- Best Nootropic Peptides for Focus and Memory: RankedThe conventional Semax-Noopept-MOTS-c ranking leans on disease-population trials. Here is what the primary literature actually shows, and who each peptide really fits.
- 8 Peptides Now Legal Again in 2026: What Each One Does and Who BenefitsThe peptides legal 2026 list: BPC-157, TB-500, Semax, CJC-1295, Thymosin Alpha-1, AOD-9604, GHK-Cu and MOTS-c reviewed with evidence grades, access routes and who
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