Longevity

MOTS-c

Mechanism

A 16-amino-acid mitochondrial-derived peptide. Activates AMPK signalling, improves insulin sensitivity, and enhances metabolic flexibility. Endogenous expression rises with exercise; declines with age.

Typical dose

5-10mg per injection, 2-3 times per week

Cycle length

8-12 weeks on, 4-8 weeks off

Form

Injectable (subcutaneous or intramuscular)

Deep dives on MOTS-c

6 Best Peptides for Anti-Ageing and Longevity (2026)The anti-ageing peptide consensus is wrong. We rank epitalon, MOTS-c, and GHK-Cu by what the primary literature actually proves vs what marketing narratives claim.
What the FDA Reclassification Actually Means for Peptide UsersFDA peptide reclassification 2026: what Category 2 to Category 1 actually means for users, what's changed, what hasn't, and what to expect from the July PCAC meeting.
Which Peptides Are Legal Again in 2026? The Full FDA ListComplete guide to the 14 peptides returning to legal compounding status in 2026 after RFK Jr.'s FDA reclassification announcement. Every compound explained.

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