Ipamorelin and Sleep Optimization: What Has Been Studied
What the research covers
No published study was found that measured sleep in people or animals given ipamorelin. Human studies measured GH levels in healthy men and recovery after bowel surgery. Ipamorelin is a lab-made peptide, five amino acids long, that triggers the release of growth hormone (GH). It acts on the ghrelin receptor.
In a dosing study, healthy men got a 15-minute infusion at one of five doses, eight men per dose. GH rose in a single peak at about 40 minutes, then fell to very low levels at every dose. The drug had a half-life of 2 hours. That study measured blood levels, not sleep.
A phase 2 trial gave ipamorelin or placebo by IV to adults after bowel surgery. The dose was 0.03 mg per kilogram twice a day, for up to 7 days. Of 117 patients enrolled, 114 were analysed. Ipamorelin was well tolerated but did no better than placebo. In pigs, ipamorelin did not raise the stress hormones ACTH or cortisol beyond what GHRH did. These hormone results come from pigs, not people.
A PubMed search on 27 September 2026 found no study of ipamorelin and sleep. Its two hits were reviews. No study comparing or combining ipamorelin with DSIP was found.
Sources
- Gobburu JV, Agersø H, Jusko WJ, et al. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res (1999). PMID 10496658 doi:10.1023/a:1018955126402
- Beck DE, Sweeney WB, McCarter MD Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis (2014). PMID 25331030 doi:10.1007/s00384-014-2030-8
- Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol (1998). PMID 9849822 doi:10.1530/eje.0.1390552
Frequently Asked Questions
Has ipamorelin been tested for sleep?
How long does the GH rise last after ipamorelin?
Has ipamorelin been studied with DSIP?
What dose was used in the published human trial?
Does ipamorelin raise cortisol or prolactin?
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This content is for educational purposes only. These compounds are intended for research use. Nothing here is medical advice.
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