CJC-1295 and Muscle Gain: What Has Been Studied
What the research covers
No published human trial was found that tested CJC-1295 for muscle gain. The human studies measured hormone levels in healthy adults. CJC-1295 is a lab-made form of GHRH, a hormone that drives the release of growth hormone (GH). After a shot, it binds to albumin, a blood protein, so it lasts much longer than natural GHRH.
Two trials tested it against placebo in healthy adults aged 21 to 61. The shots went under the skin. The trials ran for 28 and 49 days. One shot raised GH levels 2 to 10 times for 6 days or more. IGF-I levels rose 1.5 to 3 times for 9 to 11 days. The estimated half-life was 5.8 to 8.1 days. No serious adverse reactions were reported. A second study gave healthy men aged 20 to 40 one shot of 60 or 90 micrograms per kilogram. A week later, mean GH was 46% higher and IGF-I was 45% higher. These studies measured hormone levels and safety, not body changes.
In a rodent (mouse) study, young animals born without their own GHRH got 2 micrograms of CJC-1295 a day for 5 weeks. They reached normal body weight and length, with normal lean mass for their size. That model tests growth in animals born without GHRH, not muscle gain in adults.
A PubMed search on 27 September 2026 found no human trial of CJC-1295 for muscle, lean mass or strength. A second search that day found no study giving CJC-1295 with ipamorelin.
Sources
- Teichman SL, Neale A, Lawrence B, et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab (2006). PMID 16352683 doi:10.1210/jc.2005-1536
- Ionescu M, Frohman LA Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab (2006). PMID 17018654 doi:10.1210/jc.2006-1702
- Alba M, Fintini D, Sagazio A, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab (2006). PMID 16822960 doi:10.1152/ajpendo.00201.2006
Frequently Asked Questions
Has CJC-1295 been tested for muscle gain in humans?
What did the human studies of CJC-1295 find?
What doses were used in the human studies?
What did the animal study of CJC-1295 find?
Has CJC-1295 been studied together with ipamorelin?
More CJC-1295 research
Deep dives on CJC-1295
- Best Peptides for Injury Recovery: What the Evidence ShowsBest peptides for injury recovery, weighed on the evidence: what BPC-157, TB-500, GHK-Cu and four others were studied in, plus FDA's legal record in 2026.
- Thymosin Alpha 1 Peptide: Benefits, Dosage and SafetyThymosin alpha 1 peptide explained: how it works, what the trials found, the doses they used, its side effects, and where it stands with the FDA in 2026.
- BPC-157 and TB-500: What the Wolverine Stack Research ShowsBPC-157 and TB-500 (Wolverine stack): no study tested the pair. See the doses the FDA reports from human studies, what was tried together and the safety record.
- How to Reconstitute Peptides: Diluents, Maths and StorageHow to reconstitute peptides, from primary sources: the diluents an FDA label names, the concentration maths, what damages a peptide, and storage figures.
This content is for educational purposes only. These compounds are intended for research use. Nothing here is medical advice.
Get the weekly UB newsletter
One email every Friday: new protocols, research breakdowns, and tactical guides. No spam. Unsubscribe anytime.