CJC-1295 and Longevity and Anti-Aging: What Has Been Studied
What the research covers
No published study was found that tested CJC-1295 for ageing or lifespan. The human studies were short and measured hormone levels in healthy adults. CJC-1295 is a lab-made form of GHRH, a hormone that drives the release of growth hormone (GH). After a shot, it binds to albumin, a blood protein, so it lasts much longer than natural GHRH.
Two trials tested it against placebo in healthy adults aged 21 to 61. The shots went under the skin. The trials ran for 28 and 49 days. One shot raised GH levels 2 to 10 times for 6 days or more. IGF-I levels rose 1.5 to 3 times for 9 to 11 days. The estimated half-life was 5.8 to 8.1 days. No serious adverse reactions were reported. After several doses, mean IGF-I stayed above baseline for up to 28 days.
A second study gave healthy men aged 20 to 40 one shot of 60 or 90 micrograms per kilogram. A week later, mean GH was 46% higher and IGF-I was 45% higher. These studies measured hormone levels and safety, not body changes.
A PubMed search on 27 September 2026 found no study of CJC-1295 and ageing or lifespan, in people or animals. The longest human trial with published results lasted 49 days. A 12-week trial was stopped and posted no results.
Sources
- Teichman SL, Neale A, Lawrence B, et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab (2006). PMID 16352683 doi:10.1210/jc.2005-1536
- Ionescu M, Frohman LA Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab (2006). PMID 17018654 doi:10.1210/jc.2006-1702
Frequently Asked Questions
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This content is for educational purposes only. These compounds are intended for research use. Nothing here is medical advice.
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