Kisspeptin-10 and Hormone Optimization: What Has Been Studied

What the research covers

Kisspeptin-10 raised LH and testosterone in short studies of men. The longest human study found lasted 12 days. Kisspeptins trigger GnRH, which drives the release of LH and FSH. Kisspeptin-10 is the shortest kisspeptin that still fully works.

A 2011 study gave healthy men single IV doses of 0.01 to 3.0 mcg/kg. LH rose within 30 minutes. The largest rise came at 1 mcg/kg, and 3 mcg/kg gave less. In 4 men, a 22.5-hour IV drip raised testosterone from 16.6 to 24.0 nmol/L. A 2013 study gave 4 men with type 2 diabetes and low testosterone an 11-hour IV drip. Their testosterone rose from 8.5 to 11.4 nmol/L.

A 2019 study gave single IV doses to men of different ages. LH rose in every age group. Testosterone rose only in the adult men group. In a 2026 study, 15 healthy men got kisspeptin-10 by slow drip under the skin. After 5 days of nonstop drip, testosterone stayed up. But LH and FSH had fallen back to placebo levels. Daily 8-hour drips kept these hormones up for 12 days.

A PubMed search on 27 September 2026 found no study in men longer than 12 days.

Sources

1. George JT, Veldhuis JD, Roseweir AK, et al. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J Clin Endocrinol Metab (2011). PMID 21632807 doi:10.1210/jc.2011-0089 Healthy men: IV boluses 0.01-3.0 mcg/kg raised LH; 22.5-hour infusion at 4 mcg/kg/h raised testosterone.
2. George JT, Veldhuis JD, Tena-Sempere M, et al. Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism. Clin Endocrinol (Oxf) (2013). PMID 23153270 doi:10.1111/cen.12103 Men with type 2 diabetes and low testosterone: IV bolus and 11-hour infusion raised LH and testosterone.
3. Ullah H, Nabi G, Zubair H, et al. Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men. Andrologia (2019). PMID 30590872 doi:10.1111/and.13219 Men of different ages, single IV bolus: LH rose in all groups; testosterone only in the adult group.
4. Yeung AC, Phylactou M, Koysombat K, et al. Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men. Eur J Endocrinol (2026). PMID 42549827 doi:10.1093/ejendo/lvag134 15 healthy men: subcutaneous infusions, continuous for 5 days or 8 hours daily for 12 days.